The Van de Plas lab focuses on the interface between three different fields: (i) mathematical engineering and machine learning; (ii) analytical chemistry and instrumentation physics; and (iii) life sciences and medicine. Our research is specifically focused on the computational analysis of molecular imaging modalities such as imaging mass spectrometry and microscopy, and on the mathematical integration of information from different imaging technologies through data-driven image fusion.
Raf Van de Plas is assistant professor at the Delft Center for Systems and Control in the Delft University of Technology (TU Delft; Netherlands). He holds an adjunct assistant professor position in biochemistry at the Vanderbilt University School of Medicine (Nashville, TN, U.S.A.), where he is a member of the Mass Spectrometry Research Center.
Scientific interests
- Signal analysis & machine learning
- Molecular imaging
- Mass spectrometry
Expertise
- Advanced signal analysis and machine learning methods for imaging
- Big data and high-dimensional image analysis problems
- Image fusion between different imaging technologies
Models and equipment
- Computational analysis pipelines for imaging mass spectrometry and microscopy (e.g. MxIF, CODEX)
- Multimodal integration and fusion pipelines
- Access to imaging mass spectrometry instrumentation
- Experience with several sample types (e.g. brain, kidney, pancreas, eye, bone) and species (e.g. human, mouse, rat)
Experience with several pathologies and biological systems (e.g. host-pathogen interactions, cancer, macular degeneration).
